Description
Anti-M2e Antibody, Non-Fucosylated (BioBet-1198ZP) is a human monoclonal IgG antibody against M2e. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Influenza
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced M2e antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
M2e
Full Name
Orthomyxoviruses
Background
The Orthomyxoviruses are a family of RNA viruses that includes six genera: Influenza virus A, Influenza virus B, Influenza virus C, Isavirus, Thogotovirus and Quaranjavirus. The first three genera contain viruses that cause influenza in vertebrates, including birds (see also avian influenza), humans, and other mammals. Isaviruses infect salmon; the thogotoviruses are arboviruses, infecting vertebrates and invertebrates, such as ticks and mosquitoes.
Alternative Names
Orthomyxoviruses; Influenza Virus
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with MADCAM1 include Ileitis and Cholangitis, Primary Sclerosing.
Related Pathways
Its related pathways are Degradation of the extracellular matrix and Innate Immune System.
Function
Cell adhesion leukocyte receptors are expressed by the mucosal venules and help guide lymphocyte traffic into the mucosal tissues including the lamina and lamina propria. It can combine integrin alpha-4/beta-7 and l-selectin to regulate the passage and retention of white blood cells. Isoform 2, which lacks a mucin-like domain, may specifically support integrin alpha-4/beta-7-dependent adhesion enhancement, rather than relying on l-selectin binding.
Post-translational modifications
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
TCN-032
Description
TCN-032 is a human monoclonal antibody targeting a conserved epitope on M2e, was explored in experimental human influenza. TCN-032 may provide immediate immunity and therapeutic benefit in influenza A infection, with no apparent emergence of resistant virus. TCN-032 was safe with no evidence of immune exacerbation based on serum cytokine expression.
Antibody Indication
Influenza
