Description
Anti-Lymphotoxin alpha Antibody, Non-Fucosylated (BioBet-1191ZP) is a human monoclonal IgG antibody against Lymphotoxin alpha. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases; Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Lymphotoxin alpha antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
LTA
Full Name
lymphotoxin alpha
Background
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkins lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.
Alternative Names
LTA; lymphotoxin alpha; LT; TNFB; TNFSF1; lymphotoxin-alpha; LT-alpha; TNF-beta; TNF superfamily, member 1; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1
Gene ID
4049
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with LTA include Psoriatic Arthritis and Leprosy 4.
Related Pathways
Its related pathways are Apoptosis Modulation and Signaling and NF-KappaB Family Pathway.
Function
A trimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. It binds to TNFRSF3/LTBR in the form of heterotrimer with LTB. Lymphotoxins are produced by lymphocytes and are cytotoxic to a variety of tumor cells in vivo and in vitro.
Field of research
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody
Post-translational modifications
Phosphorylation at Ser-416 inhibits enzymatic activity.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1191ZP
Description
The antibody, including specified portions or variants, specific for at least one human lymphotoxin alpha (LTα) protein, have been implicated in inflammatory diseases, autoimmune diseases, viral, bacterial and parasitic infections, malignancies, and/or neurogenerative diseases.
Antibody Indication
Inflammatory Diseases; Autoimmune Diseases
Inflammatory Diseases; Autoimmune Diseases
