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Anti-LTA Antibody, Highly Galactosylated (BioBet-GA-343ZP) (CAT#: BioBet-GA-343ZP) Datasheet

Target
LTA
Isotype
IgG1, κ
Description
Anti-LTA Antibody, Highly Galactosylated (BioBet-GA-343ZP) is a humanized IgG1, κ antibody against LTA which contains with a high level of galactosylation.
Antibody Indication
Rheumatoid arthritis (RA)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced LTA antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
LTA
Alternative Names
Pateclizumab; 1202526-59-7; Anti-LTa; RG7416; MLTA3698A; PRO283698; LTA; lymphotoxin alpha (TNF superfamily, member 1); TNFB; lymphotoxin-alpha; LT; TNFSF1; LT-alpha; TNF-beta; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1;
Gene ID
4049
UniProt ID
P01374
Cellular Localization
Extracellular region or secreted
Genecards
6709
Involvement in Disease
Its related pathways are Apoptosis Modulation and Signaling and NF-KappaB Family Pathway.
Related Pathways
A trimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. It binds to TNFRSF3/LTBR in the form of heterotrimer with LTB. Lymphotoxins are produced by lymphocytes and are cytotoxic to a variety of tumor cells in vivo and in vitro.
Function
Cell Biology and Cellular Response antibody; Developmental Biology antibody; Neuroscience antibody; Signaling Transduction antibody
Field of research
Phosphorylation at Ser-416 inhibits enzymatic activity.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, κ
Antibody Clone
BioBet-GA-343ZP
Host
Humanized
Species Reactivity
Human
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to TNF beta. Pateclizumab is an immunomodulator. It binds to lymphotoxin alpha.
Antibody Indication
Rheumatoid arthritis (RA)

Rheumatoid arthritis (RA)

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Anti-LTA Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP521) (CAT#: AES-0622-ZP521)
Anti-LTA Antibody, On-Target (AES-0622-ZP849) (CAT#: AES-0622-ZP849)
Anti-LTA Antibody, Non-Fucosylated (BioBet-343ZP) (CAT#: BioBet-343ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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