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Anti-Lectin-like transcript 1 Antibody, Non-Fucosylated (BioBet-722ZP) (CAT#: BioBet-722ZP) Datasheet

Target
Lectin-like transcript 1
Isotype
IgG
Description
Anti-Lectin-like transcript 1 Antibody, Non-Fucosylated (BioBet-722ZP) is a chimeric monoclonal IgG antibody against Lectin-like transcript 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Lectin-like transcript 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
CLEC2D
Full Name
C-type lectin domain family 2, member D
Background
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
Alternative Names
CLEC2D; C-type lectin domain family 2, member D; CLAX; LLT1; OCIL; C-type lectin domain family 2 member D; LLT-1; C-type lectin related f; lectin-like transcript 1; lectin-like NK cell receptor; osteoclast inhibitory lectin; C-type lectin superfamily 2, member D
Gene ID
29121
UniProt ID
P19022
Cellular Localization
Plasma membrane
Related Pathways
Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.
Function
The KLRB1 receptor protects target cells from natural killer cell-mediated lysis. Inhibit osteoclast formation and inhibit bone resorption. Regulate the release of interferon. Combines high molecular weight sulfated glycosaminoglycans.
Post-translational modifications
1.N-glycosylated 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn95 and Asn147
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-722ZP
Host
Chimeric
Species Reactivity
Human
Description
This is a monoclonal antibody that is capable of specifically binding to lectin-like transcript 1 (LLT1), to polynucleotides encoding such antibody and to cells that express such antibody. antibody have utility in the treatment of autoimmune diseases and cancer, in which LLT1- and CD161-expressing cells play a role in disease pathogenesis.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

Related Products

Anti-Lectin-like transcript 1 Antibody, Non-Fucosylated (BioBet-723ZP) (CAT#: BioBet-723ZP)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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