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Anti-La protein Antibody, Non-Fucosylated (BioBet-1311ZP) (CAT#: BioBet-1311ZP) Datasheet

Target
La protein
Isotype
IgG
Description
Anti-La protein Antibody, Non-Fucosylated (BioBet-1311ZP) is a humanized monoclonal IgG antibody against La protein. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced La protein antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
SSB
Full Name
Sjogren syndrome antigen B (autoantigen La)
Background
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5 and 3 ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Alternative Names
SSB; Sjogren syndrome antigen B (autoantigen La); La; LARP3; La/SSB; lupus La protein; SS-B; autoantigen La; la autoantigen; SS-B/La protein; lupus La antigen; sjoegren syndrome type B antigen; La ribonucleoprotein domain family, member 3
Gene ID
6741
Cellular Localization
Nucleus
Involvement in Disease
Diseases associated with SSB include Sjogren Syndrome and Lupus Erythematosus.
Related Pathways
Its related pathways are Gene Expression and RNA Polymerase III Transcription Initiation.
Function
It binds to the 3'poly(U) end of the nascent RNA polymerase III transcript to protect it from exonuclease digestion and promote its folding and maturation. When Coxsackie virus B3 is infected, it binds to the ribosome entry site (IRES) inside the virus to stimulate IRES-mediated translation.
Post-translational modifications
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1311ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody against the human La protein can be used in immuno targeting, in particular the immuno targeting of tumour cells.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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