Description
Anti-L1-CAM Antibody, Non-Fucosylated (BioBet-1161ZP) is a humanized monoclonal IgG antibody against L1-CAM. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced L1-CAM antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
L1CAM
Full Name
L1 cell adhesion molecule
Background
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
Alternative Names
L1CAM; L1 cell adhesion molecule; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1
Gene ID
3897
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with L1CAM include Masa Syndrome and Corpus Callosum, Partial Agenesis Of, X-Linked.
Related Pathways
Its related pathways are Neuroscience and Cell surface interactions at the vascular wall.
Function
Neuronal adhesion molecules are involved in cell adhesion dynamics and the production of transmembrane signals of tyrosine kinase receptors.In the development of the brain, it is essential in several processes, including neuronal migration, axon growth and fasciculus, and synaptic formation.In the mature brain, it is involved in dynamic changes in neuronal structure and function, including synaptic plasticity.
Field of research
Neuroscience antibody; Signaling Transduction antibody
Post-translational modifications
1.Glycosylation at Asn100, Asn203, Asn247, Asn294, Asn433, Asn479, Asn490, Asn505, Asn588, Asn671, Asn726, Asn777, Asn825, Asn849, Asn876, Asn979, Asn1022, Asn1030, Asn1071, and Asn1105 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1161ZP
Description
The monoclonal antibody can bind to LlCAM that is a surface antigen of the cancer cell, and suppress the activity of LlCAM, thereby inhibiting the growth and metastasis of the cancer cells. More specifically, the monoclonal antibody binds to an IgI domain of LlCAM, and thus it can be used for diagnosis or treatment of cancers expressing LlCAM.
Antibody Indication
Cancer
