Anti-L-plastin Antibody, Non-Fucosylated (CAT#: BioBet-1175ZP) Datasheet

LCP1

lymphocyte cytosolic protein 1 (L-plastin)

Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.

LCP1; lymphocyte cytosolic protein 1 (L-plastin); LPL; CP64; PLS2; LC64P; HEL-S-37; L-PLASTIN; plastin-2; LCP-1; plastin 2; epididymis secretory protein Li 37; Lymphocyte cytosolic protein-1 (plasmin); bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)

Plasma membrane, Cytoskeleton

Diseases associated with LCP1 include B-Cell Non-Hodgkin Lymphoma and Orbital Granuloma.

Its related pathways are NF-kappaB Signaling.

Actin binding protein. Play a role in TCR/CD3, CD2 or CD28 co-stimulation of t cell activation. Regulate the expression of IL2RA/CD25 and CD69 on the cell surface.

Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1175ZP

Camelid

Human

The antibody, especially camelid antibody, binding to the tandem actin binding domain in L-plastin, but not to the single actin binding domains. It further relates to the use of those antibody to limit cell invasion and metastasis in cancer.

Cancer

Cancer