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Anti-Kv3.1b K+ channel Fc Silent Antibody (F124) (CAT#: BioBet-F956P) Datasheet

Product Type
Fc Silent Antibody
Description
The Fc-mediated effector functions of antibodies include antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), and complement-dependent cytotoxicity (CDC), and have been shown to be crucial for the therapeutic efficacy of most clinically approved antibodies. However, engaging immune effectors through FcγR and complement interactions may be detrimental to certain mAb mechanisms of action and so Fc-null or -silenced antibodies may be desired.

Creative Biolabs uses site-directed mutagenesis technology to generate Fc-silenced antibody with reduced effector functions. The mutated Fc domains eliminate the binding of Fc receptors (FcγR, FcR), thereby leading to a significant reduction in ADCC and CDC in comparison to WT IgG.
Immunogen
BALB/c mice were immunised by injection of HBV particles obtained from HBsAg-positive patient blood sera. Splenocytes from immunised mice were then fused with the Sp2/0-Ag myeloma cell line.
Species
Virus
Cross reactivity
Hepatitis B virus
Host
Mouse
Clonality
Monoclonal
Isotype
IgG2a kappa
Clone Number
F124
Conjugation
Unconjugated
Buffer
PBS only
Application
WB, N, RIA
Storage Instructions
Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Target
Kv3.1b K+ channel
Alternative Names
KCNC1, KV3.1, KV4, NGK2, EPM7, potassium voltage-gated channel subfamily C member 1

Related Products

Anti-Kv3.1b K+ channel Fc Silent Antibody (N114/10.1) (CAT#: BioBet-F948P)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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