Anti-KIR3DL2 Antibody, Non-Fucosylated (BioBet-1146ZP) (CAT#: BioBet-1146ZP) Datasheet

KIR3DL2

killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

KIR3DL2; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2; p140; NKAT4; CD158K; NKAT-4; NKAT4B; killer cell immunoglobulin-like receptor 3DL2; KIR antigen 3DL2; killer Ig receptor; p70 NK receptor CL-5; MHC class I NK cell receptor; CD158 antigen-like family member K; p70 killer cell inhibitory receptor; natural killer-associated transcript 4; p70 natural killer cell receptor clone CL-5

Plasma membrane

Diseases associated with KIR3DL2 include Vogt-Koyanagi-Harada Disease and Mycosis Fungoides.

Its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System.

NK cell and T cell receptor for MHC class I molecules. Negative regulation of NK cell and T cell effector functions by binding to the peptide-free HLA-F open conformer. Acts as HLA-F receptor on astrocytes. By interacting with HLA-F, it can protect motor neurons from astrocyte-induced toxicity.

1.Glycosylation at Asn179, Asn239, Asn273, and Asn306 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1

BioBet-1146ZP

Humanized

Human

IPH41 is a humanized cytotoxic antibody (IgG1) which targets and destroys cells expressing KIR3DL2. KIR3DL2 is an inhibitory receptor of the KIR family, normally expressed on a fraction of normal NK cells but specifically expressed in most subtypes of the orphan indication of cutaneous T-cell lymphomas (CTCL). CTCL is a group of rare cutaneous lymphomas of T lymphocytes with poor prognosis and few therapeutic options at advanced stages.

Cutaneous Lymphoma

Cutaneous Lymphoma