Anti-ITGA2 Antibody, Highly Galactosylated (BioBet-GA-323ZP) (CAT#: BioBet-GA-323ZP) Datasheet

ITGA2

Integrin Subunit Alpha 2

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Vatelizumab; 1238217-55-4; SAR339658; GBR500; ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49B; integrin alpha-2; CD49b; integrin alpha 2; collagen receptor; VLA-2 subunit alpha; platelet antigen Br; platelet glycoprotein Ia;

Membrane

Its related pathways are Integrin Pathway and Interleukin-11 Signaling Pathway.

1.Integrin alpha-2/beta-1 is a receptor for laminin, collagen, c-protoprotein, fibronectin and e-cadherin. It recognizes the proline hydroxylation sequence G-F-P-G-E-R in collagen. It is responsible for the adhesion of platelets and other cells to collagen, regulating the expression of collagen and collagenase genes, and the production and organization of newly synthesized extracellular matrix. 2.Microbial infection) Integrin ITGA2: ITGB1 acts as a receptor for human rotavirus a. 3.(Microbial infection) Integrin ITGA2: ITGB1 acts as a receptor for human echovirus 1 and 8.

1.Glycosylation at Asn105, Asn112, Asn343, Asn432, Asn460, Asn475, Asn699, Asn1057, Asn1074, and Asn1081 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG4, κ

BioBet-GA-323ZP

Humanized

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to ITGA2. Vatelizumab is an immunomodulator. It binds to integrin alpha 2

Multiple sclerosis (MS)

Multiple sclerosis (MS)