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Anti-IRTA5 Antibody, Non-Fucosylated (7G8) (CAT#: BioBet-872ZP) Datasheet

Target
IRTA5
Isotype
IgG
Description
ADCC-Enhanced anti-IRTA5 (7G8) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
B cell malignancies
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IRTA5 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FCRL1
Full Name
Fc receptor-like 1
Background
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants.
Alternative Names
FCRL1; Fc receptor-like 1; FCRH1; IFGP1; IRTA5; CD307a; Fc receptor-like protein 1; hIFGP1; fcR-like protein 1; IFGP family protein 1; fc receptor homolog 1; immunoglobulin superfamily Fc receptor, gp42; immune receptor translocation-associated protein 5
Gene ID
115350
Cellular Localization
Plasma membrane
Function
May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation.
Post-translational modifications
Phosphorylated on tyrosines upon activation.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
7G8
Host
Human
Species Reactivity
Human
Description
The monoclonal antibody that specifically bind to IRTA-5 with high affinity can be used for treating various B cell malignancies, including non-Hodgkin's lymphoma.
Antibody Indication
B cell malignancies

B cell malignancies

Related Products

Anti-IRTA5 Antibody, Non-Fucosylated (2G5) (CAT#: BioBet-871ZP)
Anti-IRTA5 Antibody, Non-Fucosylated (5A2) (CAT#: BioBet-873ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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