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Anti-IRTA2 Antibody, Non-Fucosylated (BioBet-876ZP) (CAT#: BioBet-876ZP) Datasheet

Target
IRTA2
Isotype
IgG
Description
Anti-IRTA2 Antibody, Non-Fucosylated (BioBet-876ZP) is a humanized monoclonal IgG antibody against IRTA2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
B-cell malignancies
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IRTA2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
FCRL5
Full Name
Fc receptor-like 5
Background
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alternative Names
FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2)
Gene ID
83416
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with FCRL5 include Hairy Cell Leukemia and Lymphoma.
Function
It may be involved in the development and differentiation of b cells in peripheral blood lymphoid organs, and may be a useful marker for b cell staging. It may have an immunomodulatory effect on b cells in the marginal zone.
Post-translational modifications
1.Glycosylation at Asn383 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-876ZP
Host
Humanized
Species Reactivity
Human
Description
The antibody that specifically bind the extracellular domain of IRTA2 are used to treat B cell malignancies that express IRTA2, such as hairy cell leukemia and non-Hodgkin's lymphoma.
Antibody Indication
B-cell malignancies

B-cell malignancies

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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