Description
Anti-IRTA-2 Antibody, Non-Fucosylated (BioBet-1125ZP) is a human monoclonal IgG antibody against IRTA-2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IRTA-2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IRTA-2
Full Name
Immune receptor Translocation Associated proteins
Background
The Immune receptor Translocation Associated (IRTA) genes/proteins consist of a five-member family of immunoglobulin-like cell surface receptors. The IRTAs were initially discovered by analysis of the breakpoints of a multiple myeloma cell line which contained a Iq21 chromosomal rearrangement. Each of the IRTA glycoproteins contains between 3 to 9 extracellular Ig-like domains. IRTAs are also characterized by having a cytoplasmic domain containing 3 to 5 tyrosine residues contained within particular motifs, suggesting the presence of immunotyrosine inhibitory motifs (ITIM) and immunotyrosine activation-like (ITAM-like) motifs.
Alternative Names
IRTA; Immune receptor Translocation Associated proteins; Fc receptor Homolog; FcRH
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with FCRL4 include Mulchandani-Bhoj-Conlin Syndrome and Lymphoma.
Function
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response.
Post-translational modifications
1.Phosphorylated on cytoplasmic tyrosines upon activation 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn374
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1125ZP
Description
The monoclonal antibody that specifically bind to IRTA-2 with high affinity are used for treating various B cell malignancies, including non-Hodgkin's lymphoma.
Antibody Indication
Cancer
