Anti-IRAK4 Antibody, Non-Fucosylated (BioBet-1124ZP) (CAT#: BioBet-1124ZP) Datasheet

IRAK4

interleukin-1 receptor-associated kinase 4

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

IRAK4; interleukin-1 receptor-associated kinase 4; IPD1; REN64; IRAK-4; NY-REN-64; renal carcinoma antigen NY-REN-64

Cytoplasm

Diseases associated with IRAK4 include Irak4 Deficiency and Invasive Pneumococcal Disease, Recurrent Isolated.

Its related pathways are Bacterial infections in CF airways and NF-KappaB Family Pathway.

Serine/threonine protein kinases play a key role in initiating the innate immune response against foreign pathogens. Participate in toll-like receptor (TLR) and IL-1R signaling pathway (PubMed:17878374). MYD88 is rapidly recruited into the receptor signal complex after TLR activation, and forms Myddosome with IRAK2. IRAK1 is initially phosphorylated, thereby stimulating the kinase activity and strong autophosphorylation of IRAK1. Phosphorylate the E3 ubiquitin ligase Pellino protein (PELI1, PELI2 and PELI3) to promote Pellino-mediated IRAK1 polyubiquitination. Then, the ubiquitin binding domain of IKBKG/NEMO binds to the polyubiquitinated IRAK1, which binds the IRAK1-map3k7/TAK1-TRAF6 complex and the NEMO-ikka-ikkb complex together. MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) in turn, leading to nuclear translocation and activation of nf-kpa-b. Alternatively, TIRAP is phosphorylated to promote its ubiquitination and subsequent degradation. After LPS stimulation, NCF1 phosphorylates and regulates the activation of NADPH oxidase, suggesting a similar mechanism during microbial infection.

Cell Biology and Cellular Response antibody; Immune System antibody; Signaling Transduction antibody

Phosphorylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1124ZP

Human

Human

The antibody that bind phosphorylated forms of IRAK4, used for detecting, diagnosing, and prognosticating immune diseases and disorders such as inflammation, autoimmune disorders, and recurrent bacterial infections.

Immune Diseases

Immune Diseases