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Anti-Interleukin 34 Antibody, Non-Fucosylated (BioBet-1095ZP) (CAT#: BioBet-1095ZP) Datasheet

Target
Interleukin 34
Isotype
IgG
Description
Anti-Interleukin 34 Antibody, Non-Fucosylated (BioBet-1095ZP) is a human monoclonal IgG antibody against Interleukin 34. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Immunological Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Interleukin 34 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL34
Full Name
interleukin 34
Background
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 ).
Alternative Names
IL34; interleukin 34; IL-34; C16orf77; interleukin-34
Gene ID
146433
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL34 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 and Tenosynovial Giant Cell Tumor.
Related Pathways
Its related pathways are PEDF Induced Signaling and Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions.
Function
Cytokines that promote the proliferation, survival and differentiation of monocytes and macrophages. Promote the release of pro-inflammatory chemokines, thus playing an important role in innate immunity and inflammation. It plays an important role in regulating the proliferation, differentiation and bone resorption of osteoclasts. Stimulate the phosphorylation of MAPK1/ERK2 and MAPK3/ERK1 through the signal pathway of CSF1R and its downstream effectors.
Post-translational modifications
Glycosylation at Asn76
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1095ZP
Host
Human
Species Reactivity
Human
Description
The anti-IL-34 antibody are used for treating myeloid pathogenic immunological diseases.
Antibody Indication
Immunological Diseases

Immunological Diseases

Related Products

Anti-Interleukin 34 Antibody, Non-Fucosylated (BioBet-1096ZP) (CAT#: BioBet-1096ZP)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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