Anti-Interleukin-21 Receptor Antibody, Non-Fucosylated (ATR-107) (CAT#: BioBet-1081ZP) Datasheet

IL21R

interleukin 21 receptor

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.

IL21R; interleukin 21 receptor; NILR; CD360; interleukin-21 receptor; IL-21 receptor; novel interleukin receptor

Membrane

Diseases associated with IL21R include Immunodeficiency 56 and Ige Responsiveness, Atopic.

Its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and AKT Siganaling Pathway.

This is a receptor for interleukin-21.

1.C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn73, Asn97, Asn104, Asn125, Asn135, and Trp214

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

ATR-107

Human

Human

PF-05230900 is a fully human monoclonal anti-IL-21 receptor (IL-21R) antibody, has a prolonged PD effect measured by IL-21R occupancy; was highly immunogenic after single dose administration and has PK properties with rapid clearance and low bioavailability.

Autoimmune Diseases

Autoimmune Diseases