Description
Anti-Interleukin-21 Receptor Antibody, Non-Fucosylated (BioBet-1081ZP) is a human monoclonal IgG antibody against Interleukin-21 Receptor. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Interleukin-21 Receptor antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL21R
Full Name
interleukin 21 receptor
Background
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Alternative Names
IL21R; interleukin 21 receptor; NILR; CD360; interleukin-21 receptor; IL-21 receptor; novel interleukin receptor
Gene ID
50615
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with IL21R include Immunodeficiency 56 and Ige Responsiveness, Atopic.
Related Pathways
Its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and AKT Siganaling Pathway.
Function
This is a receptor for interleukin-21.
Post-translational modifications
1.C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame. 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn73, Asn97, Asn104, Asn125, Asn135, and Trp214
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ATR-107
Description
PF-05230900 is a fully human monoclonal anti-IL-21 receptor (IL-21R) antibody, has a prolonged PD effect measured by IL-21R occupancy; was highly immunogenic after single dose administration and has PK properties with rapid clearance and low bioavailability.
Antibody Indication
Autoimmune Diseases
