Description
Anti-Interleukin 21 Antibody, Non-Fucosylated (BioBet-1080ZP) is a humanized monoclonal IgG antibody against Interleukin 21. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases; Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Interleukin 21 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL21
Full Name
interleukin 21
Background
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alternative Names
IL21; interleukin 21; Za11; IL-21; CVID11; interleukin-21; interleukin-21 isoform
Gene ID
59067
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL21 include Immunodeficiency, Common Variable, 11 and Dacryoadenitis.
Related Pathways
Its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and PEDF Induced Signaling.
Function
Cytokines with immunomodulatory activity. May promote the transition between innate immunity and adaptive immunity. Induces the production of IgG (1) and IgG (3) in b cells (similarity). Natural killer (NK) cells may co-proliferate and mature with IL15. May regulate the proliferation of mature B cells and T cells in response to activation stimuli. Synergistic with IL15 and IL18 to stimulate t cells and NK cells to produce interferon. T cell-mediated immune response may inhibit the activation and maturation of dendritic cells (DC).
Post-translational modifications
1.Glycosylation at Asn97 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1080ZP
Description
Anti-interleukin 21 monoclonal antibody, named NN 8828, is a recombinant fully human monoclonal antibody that was in Phase 2 development for IBD.
Antibody Indication
Inflammatory Diseases; Rheumatoid Arthritis
Inflammatory Diseases; Rheumatoid Arthritis
