Description
Anti-Interferon Alpha Receptor 1 Antibody, Non-Fucosylated (BioBet-1025ZP) is a humanized monoclonal IgG antibody against Interferon alpha receptor 1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Crohn's Disease; Ulcerative Colitis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Interferon alpha receptor 1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IFNAR1
Full Name
interferon (alpha, beta and omega) receptor 1
Background
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.
Alternative Names
IFNAR1; interferon (alpha, beta and omega) receptor 1; AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC; interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain
Gene ID
3454
UniProt ID
Q9UK05
Cellular Localization
Plasma membrane, Endosome, Lysosome
Involvement in Disease
Diseases associated with IFNAR1 include Hepatitis C and Yellow Fever.
Related Pathways
Its related pathways are Immune response IFN alpha/beta signaling pathway and Immune response Role of DAP12 receptors in NK cells.
Function
The components of type I interferon receptors, including interferon alpha, IFNB1 and IFNW. IFNAR2 is generally used as a heterodimer. Type I interferon binding activates the JAK-STAT signaling cascade and triggers the tyrosine phosphorylation of many proteins, including JAKs, TYK2, STAT proteins, and IFNR-and-subunits. It can form an active IFNB1 receptor on its own and activate a signal cascade that does not involve activation of the JAK-STAT pathway (through similarity).
Field of research
Cancer antibody; Immune System antibody
Post-translational modifications
Ubiquitinated, leading to its internalization and degradation. Polyubiquitinated via 'Lys-48'-linked and 'Lys-63'-linked ubiquitin chains, leading to receptor internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex. Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination. Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Phosphorylated on tyrosine residues in response to interferon. Palmitoylation at Cys-463 is required for the activation of STAT1 and STAT2.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
64G12
Description
The humanized monoclonal antibody which bind to IFNAR-1 are using for therapy of Celiac Disease, Crohn's Disease, and Ulcerative Colitis (collectively referred to as Inflammatory Bowel Disease, or IBD).
Antibody Indication
Crohn's Disease; Ulcerative Colitis
Crohn's Disease; Ulcerative Colitis
