Description
Anti-Interferon Alpha Antibody, Non-Fucosylated (BioBet-1028ZP) is a human monoclonal IgG antibody against Interferon alpha. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases; Systemic lupus erythematosus
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Interferon alpha antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IFN-α
Full Name
Interferon alpha
Background
The IFN-α proteins are produced by leukocytes. They are mainly involved in innate immune response against viral infection. They come in 13 subtypes that are called IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21. These genes for these IFN-α molecules are found together in a cluster on chromosome 9.
Alternative Names
Interferon alpha; IFN-α
Gene ID
282618
UniProt ID
Q9UK05
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IFNA1 include Hepatitis and Viral Infectious Disease.
Related Pathways
Its related pathways are all-trans-Retinoic Acid Mediated Apoptosis and Tuberculosis.
Function
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Post-translational modifications
1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1028ZP
Description
The antibody that selectively neutralize a bioactivity of at least two interferon alpha ('IFNα') protein subtypes for the protein subtypes A, 2, B2, C, F, G, H2, 1, Jl, K, 4a, 4b and WA, are useful to detect IFNα subtypes in sample or tissue and/or for therapeutic applications that include, but are not limited to the treatment and/or amelioration of an IFNα related disorder such as SLE, lupus, type I diabetes, psoriasis, AIDS and Graft versus Host Disease.
Antibody Indication
Autoimmune Diseases; Systemic lupus erythematosus
Autoimmune Diseases; Systemic lupus erythematosus
