Anti-Integrin beta-2 Antibody, Non-Fucosylated (BioBet-1136ZP) (CAT#: BioBet-1136ZP) Datasheet

ITGB2

integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants.

ITGB2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1; integrin beta-2; integrin beta chain, beta 2; complement receptor C3 beta-subunit; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion glycoprotein (LFA-1/CR3/P150, 959 beta subunit precursor); LDP-01, MLN01, MLN2201, 1B4, YFC51. 1

Plasma membrane

Diseases associated with ITGB2 include Leukocyte Adhesion Deficiency, Type I and Pertussis.

Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.

Integrin Itgal / itgb2 is the receptor of ICAM1, icam2, icam3 and icam4. Integrin Itgal / itgb2 is also a receptor for secretory ubiquitin like protein ISG15; this interaction is mediated by Itgal. Integrins itgam / itgb2 and itgax / itgb2 are receptors for the third complement component iC3b and fibrinogen. Integrin itgax / itgb2 recognizes the g-p-r sequence in the alpha chain of fibrinogen. Integrin itgam / itgb2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin itgam / itgb2 is also a receptor for factor X. Integrin itgad / itgb2 is the receptor of icam3 and VCAM1. Contribute to natural killer cytotoxicity. It is involved in leukocyte adhesion and leukocyte transport, including T cells and neutrophils. Ptk2b / Pyk2 mediated activation triggers neutrophil migration during lung injury. Integrin Itgal / itgb2 is associated with icam3 and contributes to macrophage apoptosis and neutrophil phagocytosis. CD177 - prtn3 mediates TNF - mediated neutrophil activation associated with subunit itgam / CD11b.

Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1136ZP

Humanized

Human

MLN2201 is a humanized monoclonal antibody being developed for conditions related to inflammation of the heart and blood vessels.

Inflammatory Diseases

Inflammatory Diseases