Description
Anti-Integrin alpha4 beta7 Antibody, Non-Fucosylated (BioBet-1112ZP) is a human monoclonal IgG antibody against Integrin alpha4 beta7. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Integrin alpha4 beta7 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
Integrin α4β7
Full Name
Integrin alpha4 beta7
Background
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
Alternative Names
Integrin α4β7; Integrin alpha4 beta7; ITGA4; CD49D; IA4; ITGB7
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with ITGB7 include Spongiotic Dermatitis and Inflammatory Bowel Disease 18.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and Integrin Pathway.
Function
Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates the migration of lymphocytes and their distribution to intestinal-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with cell surface adhesion molecule MADCAM1, which is usually expressed by the endothelium of the gastrointestinal tract. It also interacts with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more regions of the fibronectin CS-1 region. The tripeptide L-D-T in MADCAM1 interacts with L-D-V in fibronectin. Combining with HIV-1 gp120, allowing the virus to enter GALT, which is considered to be the main cause of AIDS. The interaction involves L-D-I, a tripeptide in HIV-1 gp120. The integrin alpha-E/beta-7 (HML-1) is the receptor for e-cadherin.
Post-translational modifications
1.Glycosylation at Asn68, Asn279, Asn434, Asn477, Asn665, Asn674, Asn531, and Asn590 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1112ZP
Description
This is an activation-specific antibody against α4β7 by recognizing the epitope only exposed in active conformation. It is a potentially powerful tool for studying α4β7 function and treatment of α4β7 related inflammatory diseases.
Antibody Indication
Inflammatory Diseases
