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Anti-Integrin alpha 2 Antibody, Non-Fucosylated (BioBet-1130ZP) (CAT#: BioBet-1130ZP) Datasheet

Target
Integrin alpha 2
Isotype
IgG
Description
Anti-Integrin alpha 2 Antibody, Non-Fucosylated (BioBet-1130ZP) is a humanized monoclonal IgG antibody against Integrin alpha 2. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Integrin alpha 2 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ITGA2
Full Name
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
Background
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants.
Alternative Names
ITGA2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2; integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit
Gene ID
3673
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with ITGA2 include Fetal And Neonatal Alloimmune Thrombocytopenia and Bleeding Disorder, Platelet-Type, 9.
Related Pathways
Its related pathways are Integrin Pathway and Interleukin-11 Signaling Pathway.
Function
2/-1 is a receptor for laminin, collagen, C-protein, fibronectin and E-cadherin. It recognizes the proline hydroxylation sequence g-f-p-g-e-r in collagen. It is responsible for the adhesion of platelets and other cells to collagen, the regulation of collagen and collagenase gene expression, and the formation and organization of newly synthesized extracellular matrix. Integrin itga2: itgb1 as receptor for human rotavirus a (microbial infection) integrin itga2: itgb1 as receptor for human ECHO virus 1 and 8.
Post-translational modifications
1.Glycosylation at Asn105, Asn112, Asn343, Asn432, Asn460, Asn475, Asn699, Asn1057, Asn1074, and Asn1081 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1130ZP
Host
Humanized
Species Reactivity
Human
Description
The anti-α2 integrin antibody comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG1 heavy chain constant region relates to treatment of cancer.
Antibody Indication
Cancer

Cancer

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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