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Anti-Integrin Alpha 11 Antibody, Non-Fucosylated (BioBet-1129ZP) (CAT#: BioBet-1129ZP) Datasheet

Target
Integrin Alpha 11
Isotype
IgG4
Description
Anti-Integrin Alpha 11 Antibody, Non-Fucosylated (BioBet-1129ZP) is a humanized monoclonal IgG4 antibody against Integrin Alpha 11. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Arthritic Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced Integrin Alpha 11 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ITGA11
Full Name
integrin, alpha 11
Background
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
Alternative Names
ITGA11; integrin, alpha 11; HsT18964; integrin alpha-11
Gene ID
22801
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with ITGA11 include Brain Oligodendroglioma.
Related Pathways
Its related pathways are Integrin Pathway and Degradation of the extracellular matrix.
Function
Integrin alpha-11/beta-1 is a receptor for collagen.
Post-translational modifications
1.Glycosylation at Asn82, Asn95, Asn291, Asn331, Asn358, Asn449, Asn462, Asn528, Asn642, Asn694, Asn857, Asn894, Asn973, Asn1031, Asn1039, and Asn1059 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG4
Antibody Clone
BioBet-1129ZP
Host
Humanized
Species Reactivity
Human
Description
This is an antibody binding specificity for an integrin α11 subunit, relates to the use in the treatment of inflammatory disorders such as arthritic diseases (e. g. rheumatoid arthritis and osteoarthritis).
Antibody Indication
Arthritic Diseases

Arthritic Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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