Anti-Immunoglobulin-like transcript 5 Antibody, Non-Fucosylated (CAT#: BioBet-1180ZP) Datasheet

LILRB3

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

LILRB3; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; HL9; ILT5; LIR3; PIRB; CD85A; ILT-5; LIR-3; LILRA6; leukocyte immunoglobulin-like receptor subfamily B member 3; immunoglobulin-like transcript 5; monocyte inhibitory receptor HL9; CD85 antigen-like family member A; leukocyte immunoglobulin-like receptor 3; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Plasma membrane

Diseases associated with LILRB3 include Takayasu Arteritis and Bare Lymphocyte Syndrome, Type I.

Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

It can be used as a receptor for class I MHC antigens. It is activated when LILRB3 and immune receptors (such as FCGR2B and b-cell receptors) stain. Downregulate antigen-induced b-cell activation by recruiting phosphatase to its immune receptor tyrosine-based inhibitor motif (ITIM).

1.Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-595 and Tyr-625 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2 2.Modification sites at PhosphoSitePlus 3.Glycosylation at Asn139, Asn280, Asn301, and Asn340

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1180ZP

Humanized

Human

TRX585 is a novel monoclonal antibody that targets ILT5, specific for immunoglobulin-like transcript 5. It may be useful in the treatment of viral infections and malignancies.

Cancer

Cancer