Anti-Immunoglobulin-like transcript 3 receptor Antibody, Non-Fucosylated (CAT#: BioBet-1181ZP) Datasheet

LILRB4

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

LILRB4; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; ILT3; LIR5; CD85K; ILT-3; LIR-5; leukocyte immunoglobulin-like receptor subfamily B member 4; immunoglobulin-like transcript 3; CD85 antigen-like family member K; monocyte inhibitory receptor HM18; leukocyte immunoglobulin-like receptor 5

Plasma membrane

Its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

Class I MHC antigen receptor. To identify a wide range of HLA-A, HLA-B, HLA-C and HLA-G alleles. It is involved in the down regulation of immune response and the development of tolerance, such as transplantation tolerance. TNF - rsf5 signal was interfered and NF - kPa - B was up-regulated. Inhibition of receptor-mediated protein phosphorylation and intracellular calcium mobilization.

1.Modification sites at neXtProt 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1181ZP

Humanized

Human

TRX385 is a monoclonal antibody that recognizes ILT3, an inhibitory receptor expressed by dendritic cells and monocytes. These pre-clinical candidates may be developed for the treatment of cancer and viral diseases.

Cancer

Cancer