Description
Anti-IL7R Antibody, Non-Fucosylated (BioBet-1107ZP) is a humanized monoclonal IgG antibody against IL7R. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL7R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL7R
Full Name
interleukin 7 receptor
Background
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene.
Alternative Names
IL7R; interleukin 7 receptor; ILRA; CD127; IL7RA; CDW127; IL-7R-alpha; interleukin-7 receptor subunit alpha; IL-7RA; CD127 antigen; IL-7R subunit alpha; IL-7 receptor subunit alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6
Gene ID
3575
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with IL7R include Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive and Severe Combined Immunodeficiency.
Related Pathways
Its related pathways are AKT Siganaling Pathway and IL-7 Signaling Pathway.
Function
Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Post-translational modifications
N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1107ZP
Description
This is a battery of cytotoxic or inhibitory monoclonal antibody directed at the human IL-7 alpha chain receptor (IL7-R). It is used in autoimmune diseases focuses on the treatment of ulcerative colitis as a first target in autoimmunity for a selective high affinity anti IL7-R monoclonal antibody.
Antibody Indication
Autoimmune Diseases
