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Anti-IL6R Antibody, Non-Fucosylated (BioBet-1106ZP) (CAT#: BioBet-1106ZP) Datasheet

Target
IL6R
Isotype
IgG
Description
ADCC-Enhanced anti-IL6R (ALX-0061) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Inflammatory Diseases; Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL6R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL6R
Full Name
interleukin 6 receptor
Background
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Alternative Names
IL6R; interleukin 6 receptor; IL6Q; gp80; CD126; IL6RA; IL6RQ; IL-6RA; IL-6R-1; interleukin-6 receptor subunit alpha; IL-6R 1; CD126 antigen; membrane glycoprotein 80; IL-6 receptor subunit alpha
Gene ID
3570
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with IL6R include Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus and Interleukin 6, Serum Level Of, Quantitative Trait Locus.
Related Pathways
Its related pathways are Signaling by GPCR and RAF-independent MAPK1/3 activation.
Function
Part of the interleukin 6 receptor. Binds to IL6 with low affinity, but does not transduce signals. Signal activation must be related to IL6ST. Activation can lead to immune response, acute phase response and regulation of hematopoietic function. The soluble form of IL6 receptor at low concentration acts as an agonist of IL6 activity.
Post-translational modifications
A short soluble form may also be released from the membrane by proteolysis.
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
ALX-0061
Host
Humanized
Species Reactivity
Human
Description
ALX-0061 is an anti-IL-6R sdAb to treat auto-immune disorders, it is being developed for the treatment of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
Antibody Indication
Inflammatory Diseases; Rheumatoid Arthritis

Inflammatory Diseases; Rheumatoid Arthritis

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All products and services are for Research Use Only. Do Not use in humans.

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