Anti-IL5RA Antibody, Non-Fucosylated (BioBet-312ZP) (CAT#: BioBet-312ZP) Datasheet

IL5RA

Interleukin 5 Receptor Subunit Alpha

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Benralizumab; 1044511-01-4; MEDI-563; BIW-8405; KHK4563; IL5RA; interleukin 5 receptor, alpha; IL5R; interleukin-5 receptor subunit alpha; CD125; CDw125; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3;

Membrane

Diseases associated with IL5RA include Disseminated Eosinophilic Collagen Disease and Hypereosinophilic Syndrome.

Its related pathways are RET signaling and Signaling by GPCR.

This is the receptor for interleukin-5. The alpha chain binds to IL5.

1.Glycosylation at Asn35, Asn131, Asn216, and Asn244 2.Modification sites at PhosphoSitePlus

Protein Based Therapies
Monoclonal antibody (mAb)

IgG1, κ

BioBet-312ZP

Humanized

Human

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL5RA. Benralizumab (INN) is a monoclonal antibody for the treatment of asthma. It is directed against the alpha-chain of the interleukin-5 receptor (CD125).

Asthma

Asthma