Anti-IL4R Antibody, Non-Fucosylated (CAT#: BioBet-1103ZP) Datasheet

IL4R

interleukin 4 receptor

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

IL4R; interleukin 4 receptor; CD124; IL4RA; IL-4RA; interleukin-4 receptor subunit alpha; IL4R nirs variant 1; IL-4 receptor subunit alpha; interleukin-4 receptor alpha chain

Plasma membrane, Extracellular region or secreted

Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1.

Its related pathways are AKT Siganaling Pathway and Development IGF-1 receptor signaling.

Receptor for interleukin 4 and interleukin 13. Combined with JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 response is involved in the regulation of IgE production, chemokines and mucus production in allergic inflammation sites. In some types of cells, signals can be sent by activating the insulin receptor substrate IRS1/IRS2.

On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

BioBet-1103ZP

Human

Human

AMG 317 is a fully human monoclonal antibody to IL-4Ralpha that blocks both IL-4 and IL-13 pathways, used in patients with moderate to severe asthma. AMG 317 did not demonstrate clinical efficacy across the overall group of patients. Clinically significant improvements were observed in several outcome measures in patients with higher baseline ACQ scores. AMG 317 was safe and well tolerated in the study population.

Asthma

Asthma