Description
Anti-IL31 Antibody, Non-Fucosylated (BioBet-306ZP) is a Caninized monoclonal IgG2, κ antibody against IL31. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Canine atopic dermatitis (AD)
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL31 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL31
Full Name
Interleukin 31
Background
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Alternative Names
Interleukin 31; IL-31
Gene ID
100302725
UniProt ID
C7G0W1
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL31 include Allergic Contact Dermatitis and Contact Dermatitis.
Related Pathways
Its related pathways are PEDF Induced Signaling and Innate Immune System.
Function
The IL31 heterodimer receptor composed of IL31RA and OSMR activates STAT3, possibly STAT1 and STAT5. May have an effect on skin immunity. Improve the survival rate of bone marrow progenitor cells in vitro (through similarity). Induce the expression of RETNLA and serum amyloid A in macrophages (by similarity).
Post-translational modifications
Glycosylation at Asn67 and Asn100
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2, κ
Antibody Clone
BioBet-306ZP
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IL31. Lokivetmab is a caninized monoclonal antibody that can be potentially used in the treatment of Canine atopic dermatitis (AD).
Antibody Indication
Canine atopic dermatitis (AD)
Canine atopic dermatitis (AD)
