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Creative Biolabs - ADCC+ Antibody

Anti-IL2RB Antibody, Non-Fucosylated (BioBet-1091ZP) (CAT#: BioBet-1091ZP) Datasheet

Target
IL2RB
Isotype
IgG
Description
Anti-IL2RB Antibody, Non-Fucosylated (BioBet-1091ZP) is a humanized monoclonal IgG antibody against IL2RB. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL2RB antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL2RB
Full Name
interleukin 2 receptor, beta
Background
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.
Alternative Names
IL2RB; interleukin 2 receptor, beta; CD122; IL15RB; P70-75; interleukin-2 receptor subunit beta; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta
Gene ID
3560
Cellular Localization
Plasma membrane
Involvement in Disease
Diseases associated with IL2RB include Immunodeficiency 63 With Lymphoproliferation And Autoimmunity and Ichthyosis.
Related Pathways
Its related pathways are Transcriptional misregulation in cancer and RET signaling.
Function
Interleukin 2 receptor. This subunit is involved in receptor-mediated endocytosis and transduction of IL2 mitotic signals. It may be related to IL15RA, involved in IL15 to stimulate phagocytosis of neutrophils.
Post-translational modifications
1.Glycosylation at Asn29, Asn43, Asn71, and Asn149 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1091ZP
Host
Humanized
Species Reactivity
Human
Description
This is a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC. The humanized Mik beta 1 in combination with humanized anti-Tac will provide a new immunosuppressive therapy for the treatment of autoimmune diseases, graft-versus-host disease, and prevention of allograft rejection.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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