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Anti-IL2RA Antibody, Non-Fucosylated (BioBet-1090ZP) (CAT#: BioBet-1090ZP) Datasheet

Target
IL2RA
Isotype
IgG1κ
Description
Anti-IL2RA Antibody, Non-Fucosylated (BioBet-1090ZP) is a human monoclonal IgG1κ antibody against IL2RA. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Autoimmune Diseases
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL2RA antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL2RA
Full Name
interleukin 2 receptor, alpha
Background
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
Alternative Names
IL2RA; interleukin 2 receptor, alpha; p55; CD25; IL2R; TCGFR; IDDM10; interleukin-2 receptor subunit alpha; TAC antigen; IL-2R subunit alpha; IL-2 receptor subunit alpha
Gene ID
3559
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Diabetes Mellitus, Insulin-Dependent, 10.
Related Pathways
Its related pathways are RET signaling and Signaling by GPCR.
Function
Interleukin 2 receptor. This receptor participates in the regulation of immune tolerance by controlling the activity of regulatory T cells (TREGs). treg inhibits the activation and expansion of autoreactive t cells.
Field of research
Immune System antibody; Pre-B Cell Marker antibody
Post-translational modifications
1.Glycosylation at Asn70, Asn89, Thr218, Thr224, Thr229, and Thr237 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1κ
Antibody Clone
BioBet-1090ZP
Host
Human
Species Reactivity
Human
Description
HuMax-TAC specifically targets the TAC antigen and strongly inhibits IL-2 binding to the IL-2R and antigen-induced T cell proliferation. It is used for the treatment of acute renal transplant rejection and has been in development for the treatment of T cell leukemia, multiple sclerosis, graft-versus-host disease, ulcerative colitis, uveitis and asthma.
Antibody Indication
Autoimmune Diseases

Autoimmune Diseases

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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