Description
Anti-IL1RL1 Antibody, Non-Fucosylated (BioBet-1074ZP) is a Rabbit monoclonal IgG1 antibody against IL1RL1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL1RL1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL1RL1
Full Name
interleukin 1 receptor-like 1
Background
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants.
Alternative Names
IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R; interleukin-1 receptor-like 1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed
Gene ID
9173
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with IL1RL1 include Allergic Conjunctivitis and Loeffler Syndrome.
Related Pathways
Its related pathways are PEDF Induced Signaling and Innate Immune System.
Function
Interleukin-33 (IL-33) receptor; signal transduction requires the association of the co-receptor IL1RAP. Stimulate MYD88, IRAK1, IRAK4, and TRAF6, then phosphorylate MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. May be involved in the function of helper T cells.
Post-translational modifications
1.Glycosylation at Asn140, Asn54, Asn191, Asn95, Asn101, Asn232, Asn254, and Asn273 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-1074ZP
Description
This is an antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region, a CDR2 region and a CDRl region of and in that the light chain variable domain comprises a CDR3 region, a CDR2 region and a CDRl region or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases.
Antibody Indication
Inflammatory Diseases
