Description
ADCC-Enhanced anti-IL1A (CA-18C3) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Cancer; Colorectal Cancer; Diabetes Type 2; Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL1A antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL1A
Full Name
interleukin 1, alpha
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimers disease.
Alternative Names
IL1A; interleukin 1, alpha; IL1; IL-1A; IL1F1; IL1-ALPHA; interleukin-1 alpha; IL-1 alpha; hematopoietin-1; preinterleukin 1 alpha; pro-interleukin-1-alpha; MABp1, Xilonix™, CA-18C3, CV-18C3, RA-18C3, T2-18C3
Gene ID
3552
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL2A include Arthritis and Cholesteatoma Of Middle Ear.
Related Pathways
Its related pathways are NF-KappaB Family Pathway and Diseases associated with the TLR signaling cascade.
Function
IL-1 is produced by activated macrophages and stimulates the proliferation of thymocytes by inducing the release of IL-2, the maturation and proliferation of b cells, and the activity of fibroblast growth factor. IL-1 protein is involved in the inflammatory response, is identified as an endogenous pyrogen, and is reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Post-translational modifications
1.Glycosylation at Asn102 and Asn141 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
CA-18C3
Description
MABp1 is a first-in-class true human antibody targeting interleukin-1α, used in refractory cancer. MABp1 was well tolerated, no dose-limiting toxicities were experienced, and disease control was observed. Further study of MABp1 anti-interleukin-1α antibody therapy for advanced stage cancer is warranted.
Antibody Indication
Cancer; Colorectal Cancer; Diabetes Type 2; Rheumatoid Arthritis
Cancer; Colorectal Cancer; Diabetes Type 2; Rheumatoid Arthritis
