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Anti-IL19 Antibody, Non-Fucosylated (BioBet-1068ZP) (CAT#: BioBet-1068ZP) Datasheet

Target
IL19
Isotype
IgG
Description
Anti-IL19 Antibody, Non-Fucosylated (BioBet-1068ZP) is a mouse monoclonal IgG antibody against IL19. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Cancer; Rheumatoid Arthritis
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL19 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL19
Full Name
interleukin 19
Background
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.
Alternative Names
IL19; interleukin 19; MDA1; NG.1; ZMDA1; IL-10C; interleukin-19; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein
Gene ID
29949
Cellular Localization
Extracellular region or secreted
Involvement in Disease
Diseases associated with IL19 include Inflammatory Bowel Disease and Psoriasis.
Related Pathways
Its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway.
Function
May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
Post-translational modifications
Glycosylation at Asn56 and Asn135
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1068ZP
Host
Mouse
Species Reactivity
Human
Description
The monoclonal antibody specific binds to human IL-19, effectively inhibits breast cancer cell proliferation and breast tumor growth, and prolongs survival of mice bearing breast cancer.
Antibody Indication
Cancer; Rheumatoid Arthritis

Cancer; Rheumatoid Arthritis

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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