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Anti-IL17RB Antibody, Non-Fucosylated (BioBet-1061ZP) (CAT#: BioBet-1061ZP) Datasheet

Target
IL17RB
Isotype
IgG
Description
Anti-IL17RB Antibody, Non-Fucosylated (BioBet-1061ZP) is a mouse monoclonal IgG antibody against IL17RB. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Asthma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL17RB antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL17RB
Full Name
interleukin 17 receptor B
Background
The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.
Alternative Names
IL17RB; interleukin 17 receptor B; CRL4; EVI27; IL17BR; IL17RH1; interleukin-17 receptor B; IL-17RB; IL-17Rh1; IL-17B receptor; IL-17 receptor B; cytokine receptor CRL4; IL-17 receptor homolog 1; cytokine receptor-like 4; interleukin 17B receptor; interleukin-17B receptor; interleukin 17 receptor homolog 1
Gene ID
55540
Cellular Localization
Plasma membrane, Extracellular region or secreted
Involvement in Disease
Diseases associated with IL17RB include Chronic Mucocutaneous Candidiasis and Seborrheic Infantile Dermatitis.
Related Pathways
Its related pathways are IL-17 Family Signaling Pathways and PEDF Induced Signaling.
Function
Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
Post-translational modifications
1.Glycosylation at Asn67, Asn103, Asn156, Asn183, Asn197, and Asn283 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1061ZP
Host
Mouse
Species Reactivity
Human
Description
The antibody which bind interleukin-17 receptor B may be useful in therapy, e. g. the treatment of asthma, ulcerative colitis or Crohn's disease.
Antibody Indication
Asthma

Asthma

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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