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Anti-IL13RA1 Antibody, Non-Fucosylated (BioBet-1049ZP) (CAT#: BioBet-1049ZP) Datasheet

Target
IL13RA1
Isotype
IgG
Description
Anti-IL13RA1 Antibody, Non-Fucosylated (BioBet-1049ZP) is a human monoclonal IgG antibody against IL13RA1. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Antibody Indication
Allergic Disorders; Asthma
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL13RA1 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL13RA1
Full Name
interleukin 13 receptor, alpha 1
Background
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Alternative Names
IL13RA1; interleukin 13 receptor, alpha 1; NR4; CD213A1; IL-13Ra; interleukin-13 receptor subunit alpha-1; CT19; IL-13R-alpha-1; CD213a1 antigen; IL-13R subunit alpha-1; cancer/testis antigen 19; IL13 receptor alpha-1 chain; IL-13 receptor subunit alpha-1; bB128O4.2.1 (interleukin 13 receptor, alpha 1)
Gene ID
3597
UniProt ID
Q9UK05
Cellular Localization
Membrane
Involvement in Disease
Diseases associated with IL13RA1 include Low-Grade Astrocytoma and Syndromic X-Linked Intellectual Disability Cabezas Type.
Related Pathways
Its related pathways are AKT Siganaling Pathway and Akt Signaling.
Function
Binding to Interleukin-13 (IL13) with low affinity. Combining with IL4RA can form a functional receptor for IL13. It can also be used as an accessory protein for the gamma chain of common cytokine receptors for interleukin-4 (IL4) signal transduction, but it cannot replace the function of IL2RG to enhance the binding activity of interleukin-2 (IL2).
Post-translational modifications
1.Glycosylation at Asn37, Asn61, Asn105, Asn138, Asn151, Asn157, Asn235, Asn265, Asn293, Asn329, and Asn341 2.Modification sites at PhosphoSitePlus 3.Ubiquitination at Lys386
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
BioBet-1049ZP
Host
Human
Species Reactivity
Human
Description
The antibody antagonists which bind to human interleukin-13 receptor alpha 1 through domain 3 of the extracellular region of the receptor and inhibit IL-13 receptor-mediated signaling by IL-13. The antibodys have uses inter alia in the treatment or prevention of IL-13-related disorders and diseases, such as allergic disorders and asthma.
Antibody Indication
Allergic Disorders; Asthma

Allergic Disorders; Asthma

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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