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Anti-IL-6R Antibody, Non-Fucosylated (BioBet-1807ZP) (CAT#: BioBet-1807ZP) Datasheet

Target
IL-6R
Isotype
IgG1
Description
Anti-IL-6R Antibody, Non-Fucosylated (BioBet-1807ZP) is a humanized monoclonal IgG1 antibody against IL-6R. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL-6R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL-6R
Full Name
IL-6R
Background
Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acutephase reactions and hematopoiesis.
Alternative Names
Il6r, CD126, IL-6R, IL-6RA, IL-6R-alpha
Gene ID
16194
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1
Antibody Clone
BioBet-1807ZP
Host
Humanized
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.

Related Products

Anti-IL-6R Antibody, Recycling (AES-0622-ZP272) (CAT#: AES-0622-ZP272)
Anti-IL-6R Antibody, On-Target (AES-0622-ZP928) (CAT#: AES-0622-ZP928)
Anti-IL-6R Antibody, Half-Life Extended (AES-0622-ZP1256) (CAT#: AES-0622-ZP1256)
Anti-IL-6R Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP600) (CAT#: AES-0622-ZP600)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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