Description
ADCC-Enhanced anti-IL-20R (R2.1.15E2.1) is a non-fucosylated therapeutic biobetter antibody engineered by Creative Biolabs' Afuco™ technology platform.
Antibody Indication
Inflammatory Diseases
Classification
Therapeutic antibody; biobetter
Cooperation Seeking
Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL-20R antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL-20R
Full Name
Interleukin 20 receptor/Interleukin 20 receptor, alpha subunit/Interleukin 20 receptor, beta subunit
Background
Interleukin-20 receptor is a type II cytokine receptor. It is a heterodimer of α and β subunits. Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines.
Alternative Names
IL-20R; Interleukin 20 receptor/Interleukin 20 receptor, alpha subunit/Interleukin 20 receptor, beta subunit; Interleukin 20 receptor; Interleukin 20 receptor, alpha subunit; Interleukin 20 receptor, beta subunit
Gene ID
50604
Cellular Localization
Membrane
Related Pathways
Its related pathways are AKT Siganaling Pathway and PEDF Induced Signaling.
Function
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.
Post-translational modifications
Glycosylation at Asn40 and Asn134
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG
Antibody Clone
R2.1.15E2.1
Description
IL-22RA (zcytor11) is a common receptor for IL-20 and IL-22. The anti-IL-22RA antibody are involved in inflammatory processes and human disease.
Antibody Indication
Inflammatory Diseases
