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Creative Biolabs - ADCC+ Antibody

Anti-IL-17 Antibody, Non-Fucosylated (BioBet-1822ZP) (CAT#: BioBet-1822ZP) Datasheet

Target
IL-17
Isotype
IgG1 ADC
Description
Anti-IL-17 Antibody, Non-Fucosylated (BioBet-1822ZP) is a humanized monoclonal IgG1 ADC antibody against IL-17. This product is an ADCC enhanced antibody produced by our Afuco™ platform.
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IL-17 antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IL-17A
Full Name
IL-17A
Background
IL17A is a proinflammatory cytokine that is a member of the interleukin17 family. IL17A plays a central role in host defense against diverse pathogens. The active IL17A functions as either a homodimer with other interleukin17 family members and signals through the interleukin17 receptor to induce inflammatory cytokine production. IL17A is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
Alternative Names
Il17, Ctla8, IL-17, Ctla-8, IL-17A
Gene ID
16171
UniProt ID
Q62386
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1 ADC
Antibody Clone
BioBet-1822ZP
Host
Humanized
Species Reactivity
Human
Description
This clone was generated using a stable CHO cell line with the FUT8 knockout gene. It was 100% non-fucosylated. In an in vitro cell-based ADCC assay, the afucosylated antibody clone showed significantly higher ADCC activity compared to its wild type version. The binding affinity of the non-fucosylated Fc variant antibody to Fc receptor is much higher than than the same antibody with fucosylated Fc. Robust and stable production of qualitative fully non-fucosylated therapeutic antibodies is achieved.

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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