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Creative Biolabs - ADCC+ Antibody

Anti-IL-13 Fc Silent Antibody (Anrukinzumab (= IMA-638)) (CAT#: FCS-287P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human Therapeutic Antibody
Clone Number
Anrukinzumab (= IMA-638)
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
IL-13
Official Name
IL13
Full Name
Interleukin 13
Background
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Alternative Names
Anrukinzumab (= IMA-638);910649-32-0;IMA-638;IL13;interleukin 13;interleukin-13;allergic rhinitis;ALRH;BHR1;Bronchial hyperresponsiveness 1 (bronchial asthma);IL 13;MGC116786;MGC116788;MGC116789;P600;Bronchial hyperresponsiveness-1 (bronchial asthma);IL-1
Gene ID
3596
Uniprot ID
P35225

Related Products

Anti-IL-13 Fc Silent Antibody (CB-LX100-A) (CAT#: CB-LX100-A)
Anti-IL-13 Fc Silent Antibody (CB-LX101-A) (CAT#: CB-LX101-A)

All products and services are for Research Use Only. Do Not use in humans.

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