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Anti-IGF2 Fc Silent Antibody (FCS-277P) (CAT#: FCS-277P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human IgG2
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
IGF2
Official Name
IGF2
Full Name
Insulin Like Growth Factor 2
Background
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Alternative Names
IGF2; insulin-like growth factor 2 (somatomedin A); C11orf43; chromosome 11 open reading frame 43; insulin-like growth factor II; FLJ44734; somatomedin-A; insulin-like growth factor type 2; IGF-II; PP9974
Gene ID
3481
Uniprot ID
P01344

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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