Book a Meeting

Anti-IGF1R Dalotuzumab Antibody, a Fc Silent Biobetter (CAT#: FCS-276P) Datasheet

Product Type
Fc Silent Antibody
Description
The antibody Fc domain is responsible for the function in the antibody, while the Fab domain is responsible for targeting. Therefore, Fc engineering represents the engineering function of antibodies, which are effector functions, such as antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), and control the serum half-life. Therefore, Fc engineering for immune silencing or further protein engineering is essential for immune cell binding to antibodies.

The Fc-silenced antibody provided by Creative Biolabs contains key point mutations that eliminate the binding of Fc receptors (FcγR, FcR), thereby eliminating the cytotoxic (ADCC) effector function of the antibody.
Species
Human
Clonality
Monoclonal
Isotype
Human IgG1, κ
Clone Number
Dalotuzumab
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application
Funcs, In vivo assay
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Storage Instructions
Product should be stored at -20°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Target
IGF1R
Official Name
IGF1R
Full Name
Insulin Like Growth Factor 1 Receptor
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Alternative Names
AMG 479; IGFR; CD221; IGFIR; JTK13
Gene ID
3480
Uniprot ID
P08069

Related Products

Anti-MAdCAM-1 [MECA-367] Fc Silent Antibody, Rat IgG2a kappa (CAT#: BioBet-F890P)
Anti-Lymphotoxin alpha [MLTA3698A (Pateclizumab)] Fc Silent Antibody, Human IgG1 kappa (CAT#: BioBet-F897P)
Anti-Marburg Virus Nucleoprotein [MARV 59-9-10-7] Fc Silent Antibody, Human IgG1 kappa (CAT#: BioBet-F892P)
Anti-IGF1R Ganitumab Antibody, a Fc Silent Biobetter (CAT#: FCS-275P)
Anti-Ly6G/Ly6C [RB6-8C5] Fc Silent Antibody, Rat IgG2a kappa (CAT#: BioBet-F895P)
Anti-Ly6G [1A8] Fc Silent Antibody, Rat IgG2a kappa (CAT#: BioBet-F902P)
Anti-Lymphotoxin alpha [3F12.2D3] Fc Silent Antibody, Mouse IgG2b kappa (CAT#: BioBet-F899P)
Anti-MAdCAM-1 [MECA-367] Fc Silent Antibody, Mouse IgG2a kappa (CAT#: BioBet-F894P)

All products and services are for Research Use Only. Do Not use in humans.

ONLINE INQUIRY

Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

  • *
  • *
  • *
USA

UK

Germany

ISO 9001 Certified - Creative Biolabs Quality Management System.