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Creative Biolabs - ADCC+ Antibody

Anti-IFNG Antibody, Highly Galactosylated (BioBet-GA-268ZP) (CAT#: BioBet-GA-268ZP) Datasheet

Target
IFNG
Isotype
IgG1, λ1
Description
The Highly Galactosylated Anti-IFNG (Emapalumab), a biobetter antibody contains with a high level of galactosylation.
Antibody Indication
Crohn's disease (CD)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced IFNG antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
IFNG
Full Name
Interferon Gamma
Background
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
Alternative Names
Fontolizumab; huzaf; 326859-36-3; HuZAF; flintozumab; IFNG; interferon, gamma; interferon gamma; IFN-gamma; immune interferon; IFG; IFI;
Gene ID
3458
UniProt ID
P01579
Cellular Localization
Extracellular region or secreted
Genecards
5438
Involvement in Disease
Its related pathways are Folate Metabolism and Tuberculosis.
Related Pathways
Produced by lymphocytes activated by specific antigens or mitogens. In addition to the antiviral activity of ifn-gamma, it also has important immune regulation functions. It is a strong activator of macrophages, has an anti-proliferation effect on transformed cells, and can enhance the antiviral and antitumor effects of type I interferon.
Field of research
1.Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161. 2.Glycosylation at Asn48 and Asn120 3.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG1, λ1
Antibody Clone
Emapalumab
Host
Human
Species Reactivity
Human
Description
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to IFNG. Emapalumab is a human monoclonal antibody that can be potentially used in the treatment of Hemophagocytic Lymphohistiocytosis.
Antibody Indication
Crohn's disease (CD)

Crohn's disease (CD)

Related Products

Anti-IFNG Antibody, Half-Life Extended (AES-0622-ZP1286) (CAT#: AES-0622-ZP1286)
Anti-IFNG Antibody, Non-Fucosylated (BioBet-267ZP) (CAT#: BioBet-267ZP)
Anti-IFNG Antibody, Highly Galactosylated (BioBet-GA-267ZP) (CAT#: BioBet-GA-267ZP)
Anti-IFNG Antibody, Recycling (AES-0622-ZP302) (CAT#: AES-0622-ZP302)
Anti-IFNG Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP630) (CAT#: AES-0622-ZP630)
Anti-IFNG Antibody, On-Target (AES-0622-ZP958) (CAT#: AES-0622-ZP958)
Anti-IFNG Antibody, Non-Fucosylated (BioBet-268ZP) (CAT#: BioBet-268ZP)

All products and services are for Research Use Only. Do Not use in humans.

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