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Anti-ICOSL Antibody, Highly Galactosylated (BioBet-GA-262ZP) (CAT#: BioBet-GA-262ZP) Datasheet

Target
ICOSL
Isotype
IgG2, κ
Description
Anti-ICOSL Antibody, Highly Galactosylated (BioBet-GA-262ZP) is a human IgG2, κ antibody against ICOSL which contains with a high level of galactosylation.
Antibody Indication
Systemic lupus erythematosus (SLE)
Classification
Therapeutic antibody; biobetter

Cooperation Seeking

Creative Biolabs is interested in collaborating with potential partners (include but not limit to major pharma or biotech firms) to further co-develop ADCC-enhanced ICOSL antibody. For commercial partners interested in our ADCC-enhanced therapeutic antibodies, Creative Biolabs welcomes collaboration. Here are two ways for your choice, and please contact us for more details.
1) Collaborate with us and co-develop the programs from discovery phase to IND enabling. Costs will be shared.
2) Become a licensed candidate of our programs.
Looking forward to cooperating with you in the near future.
Official Name
ICOSLG
Full Name
Inducible T Cell Costimulator Ligand
Background
ICOSLG (Inducible T Cell Costimulator Ligand) is a Protein Coding gene.
Diseases associated with ICOSLG include Inclusion Body Myositis and Immunodeficiency With Hyper-Igm, Type 2.
Among its related pathways are Allograft rejection and Innate Immune System.
Gene Ontology (GO) annotations related to this gene include receptor binding.
An important paralog of this gene is LOC102723996.
Alternative Names
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
Gene ID
23308
UniProt ID
O75144
Cellular Localization
Plasma membrane
Genecards
17087
Involvement in Disease
Its related pathways are ICos-ICosL Pathway in T-Helper Cell and Innate Immune System.
Related Pathways
T cell specific cell surface receptor ICOS ligand. As a co-stimulatory signal for t cell proliferation and cytokine secretion; it can also induce b cell proliferation and differentiation into plasma cells. It plays an important role in mediating the response of local tissues to inflammatory conditions and co-stimulating memory T cell function (through similarity) to regulate secondary immune responses.
Field of research
1.Glycosylation at Asn137, Asn173, Asn186, Asn70, Asn102, and Asn225 2.Modification sites at PhosphoSitePlus
Biologic Classification
Protein Based Therapies
Monoclonal antibody (mAb)
Antibody Isotype
IgG2, κ
Antibody Clone
BioBet-GA-262ZP
Host
Human
Species Reactivity
Human
Description
Recombinant monoclonal antibody to ICOSLG. Prezalumab is a human monoclonal antibody that can be potentially used in the treatment of Systemic lupus erythematosus (SLE).
Antibody Indication
Systemic lupus erythematosus (SLE)

Systemic lupus erythematosus (SLE)

Related Products

Anti-ICOSL Antibody, On-Target (AES-0622-ZP858) (CAT#: AES-0622-ZP858)
Anti-ICOSL Antibody, Non-Fucosylated (BioBet-262ZP) (CAT#: BioBet-262ZP)
Anti-ICOSL Antibody, Recycling (AES-0622-ZP202) (CAT#: AES-0622-ZP202)
Anti-ICOSL Antibody, FcγRIIB Binding Enhanced (AES-0622-ZP530) (CAT#: AES-0622-ZP530)
Anti-ICOSL Antibody, Half-Life Extended (AES-0622-ZP1186) (CAT#: AES-0622-ZP1186)

All products and services are for Research Use Only. Do Not use in humans.

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Creative Biolabs has established a team of customer support scientists ready to discuss ADCC/CDC optimization strategies, antibody production, bioinformatics analysis and other molecular biology/biotechnology issues.

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