Anti-ICOS Antibody, Non-Fucosylated (BioBet-1022ZP) (CAT#: BioBet-1022ZP) Datasheet

ICOS

inducible T-cell co-stimulator

The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.

ICOS; inducible T-cell co-stimulator; AILIM; CD278; CVID1; inducible T-cell costimulator; inducible costimulator; activation-inducible lymphocyte immunomediatory molecule

Plasma membrane, Extracellular region or secreted

Diseases associated with ICOS include Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.

Its related pathways are RET signaling and Signaling by GPCR.

It enhances all the basic responses of t cells to foreign antigens, namely proliferation, secretion of lymphokines, up-regulation of intercellular interaction molecules, and effectively helps b cells to secrete antibodies. It is essential for the effective interaction between T cells and b cells and the normal antibody response to T cell dependent antigens. Does not up-regulate the production of interleukin-2, but super induces the synthesis of interleukin-10. Prevent the apoptosis of pre-activated t cells. It plays a key role in cd40-mediated isotype switching (through similarity) of immunoglobulins.

N-glycosylated.

Protein Based Therapies
Monoclonal antibody (mAb)

IgG

53-3

Chimeric

Human

The antibody directed against ICOS can induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

Autoimmune Diseases

Autoimmune Diseases