Product Type
Fc Silent Antibody
Description
Anti-Human TNF alpha-Fc silent antibody is derived from clone D2E7, which is a Human monoclonal antibody targeting the TNF alpha. And it is intended for the research of Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease.
Research Area
Cell Biology, Immunology
Antigen Distribution
TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, B cells, NK cells, LAK cells.
Disease
Rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease
Immunogen
Recombinant Human TNF alpha protein
Application
Block, ELISA, FuNeutcS, FC, IF, IHC, IP, Neut
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Tumor necrosis factor
Full Name
Tumor necrosis factor
Background
TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α inactivation has proven to be important in downregulating the inflammatory reactions associated with autoimmune diseases such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, moderate to severe chronic psoriasis, and juvenile idiopathic arthritis.
Alternative Names
DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha
