Product Type
Fc Silent Antibody
Description
Anti-Human Sortilin (AL001)-Fc silent antibody is a Humanized monoclonal antibody targeting the Siglec-8. And it is intended for the research of Eosinophilic gastritis.
Research Area
Cell Biology, Immunology
Disease
Frontotemporal dementia
Size
100 ug
Species
Human
Clonality
Monoclonal
Clone Number
AL001
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
Sortilin
Full Name
Sortilin
Background
SORT functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex.
Alternative Names
Sortilin; SORT; Glycoprotein 95; Gp95
Uniprot ID
Q99523
