Product Type
Antibody
Description
The polyclonal antibody recognizes human surfactant protein C (SP-C). There are four surfactant-specific proteins, which are called Surfactant Protein A (SP-A), SP-B, SP-C and SP-D. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins, which may be the most suitable indicators of the evolutionary origin of surfactants. SP-C is a 4 kD 34-35 amino acid peptide, which can be proteolyzed from 21 kD precursor protein. SP-C begins in the early embryogenesis phase of lung formation, and SP-C transcripts are evenly detected in the epithelial cells lining the original airway. During lung development, SP-C expression decreases in cells in the proximal conductive part of the lung. Finally, SP-C is selectively expressed in type II epithelial cells of the alveoli. SP-C is secreted into the air to enhance the diffusion and stability of surfactant phospholipids in the alveoli. SP-C plays an important role in the diffusion and stabilization of the phospholipid membrane in the alveoli. SP-C is essential for mammalian breathing, so it is largely protected. The lack of SP-C and other surfactant components is related to respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS). Produce polyclonal antibodies against recombinant human pro-SP-C (AA 1-33) GST fusion protein. The polyclonal antibody cross-reacts with mouse SP-C.
Disease
Infectious diseases, Nephrology
Size
100 µg
Species
Human
Cross reactivity
Mouse
Clonality
Polyclonal
Buffer
PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Application
Frozen sections, Paraffin sections, Western blot
Application Notes
For immunohistology and western blotting, diluents will be used, depending on the detection system used. It is recommended that users test reagents and determine their own optimal dilution. The typical initial working dilution is 1:50.
Storage Instructions
Product should be stored at 4°C. Under recommended storage conditions, product is stable for at least one year.
Alternative Names
SFTPC; previous SFTP2
