Product Type
Fc Silent Antibody
Description
Anti-Human PCSK9-Fc silent antibody is a Chimeric monoclonal antibody targeting the Ebola virus. And it is intended for the research of Ebola virus infection.
Research Area
Cell Biology, Immunology
Antigen Distribution
Biased expression in lung (RPKM 5.3), liver (RPKM 3.3) and 9 other tissues.
Disease
Heterozygous familial hypercholesterolemia
Size
100 ug
Species
Human
Clonality
Monoclonal
Conjugation
Unconjugated
Source
Recombinant
Buffer
PBS, pH 7.4
Application Notes
The use of diluent depends on the detection system used. It is recommended that users test reagents and determine their own optimal dilution.
Handling Advice
This product is for research use only. It is not intended for use in therapeutic or diagnostic procedures for humans or animals.
Storage Instructions
Product should be stored at -80°C. Repeated freeze and thaw cycles will cause loss of activity. Use product within 24 hours after thawing and keep on ice. Remainder amounts should be aliquoted and immediately re-freezed for future use. Aliquots should never be thawed more than once. Under recommended storage conditions, product is stable for at least one year.
Official Name
PCSK9
Full Name
Proprotein convertase subtilisin/kexin type 9
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Alternative Names
PCSK9; Proprotein convertase subtilisin/kexin type 9; FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3
Gene ID
255738
Uniprot ID
Q8NBP7
